Gastric mucosal “barrier”

GASTRIC MUCOSAL PROTECTION Peripheral mechanisms of gastric mucosal protection: mediators, receptors Gastric mucosal barrier to acid

Gastric mucosal integrity can be influenced both by peripheral and central mechanisms. In the last decades the peripheral mechanisms of gastric mucosal defense have been intensively studied, and many details have been clarified. Some of these results have served as a basis for the development of new strategies, therapeutic targets in the treatment of gastric mucosal lesions. On the other hand, ...

Gastric surfactant and the hydrophobic mucosal barrier.

Effect of gastric secretory inhibitors on the gastric mucosal barrier.

The effects of the synthetic prostaglandin 16, 16 dimethyl-E2 methyl ester (16-diMe-PGE2) and the histamine H2-receptor antagonist metiamide on the gastric mucosal barrier have been studied using the Heidenhain pouch dog model. The 16-diMe-PGE2 caused significant change in the ionic permeability of the mucosa when instilled into the pouch in a concentration of 300 mug/20 ml. Intravenous adminis...

Gastric mucosal barrier: barrier to hydrogen ions imparted by gastric surfactant in vitro.

A simple experiment is described which shows how the highly surface active ingredient of gastric surfactant (DPPC) can be deposited on a filter paper to reduce the rate of transmission of hydrogen ions by one to two orders of magnitude. This finding is compatible with previous studies implying that the hydrophobic layer of surface active phospholipid provides the gastric mucosal barrier as a di...

Biliary Mucosal Barrier and Microbiome

BACKGROUND The biliary system is in continuous contact with the complex microbiota of the intestine. Microbial products have recently been proposed as potential triggers for biliary diseases. METHODS The aim of this review is to provide a summary of the current knowledge regarding the role of the biliary and intestinal microbiome in biliary inflammatory diseases. RESULTS Previously, it was ...